Calculation of transmitral flow by Doppler echocardiography: a comparison of methods in a canine model

Although several Doppler echocardiographic methods for measuring transmitral flow have been described, the optimal method for calculation of flow remains unclear. Seven time/shape combinations were tested in an experimental preparation in which mitral flow could be precisely controlled and measured. Annular shape was considered to be either circular or elliptical, and the mitral orifice area was calculated from the anteroposterior and/or the mediolateral dimension(s) recorded at early and middiastole. In addition the orifice area was calculated from the maximal mitral leaflet area corrected for diastolic variation. Transmitral flow ranged between 0.4 and 4.6 L/min. Good correlations with measured transmitral flow (r = 0.83 to 0.92) were observed for all methods of calculating the mitral orifice area. Methods that assumed a circular geometry and used the mediolateral annular diameter overestimated flow. Conversely, flows calculated by means of the anteroposterior diameter with the assumption of a circular anulus underestimated flow. The best approximations of transmitral flow were obtained with the assumption of an elliptical configuration that used measurements made in early diastole (Y = 1.04x + 0.2) and with the Fisher method (y = 0.94x + 0.08). Thus in the canine model approximation of the mitral orifice as an ellipse provides the most accurate measurement of transmitral flow.