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Related Concept Videos

Polymers02:34

Polymers

41.6K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Supramolecular polymeric biomaterials.

Joseph L Mann1, Anthony C Yu, Gillie Agmon

  • 1Department of Materials Science and Engineering, Stanford University, 476 Lomita Mall, Stanford, CA 94305, USA. eappel@stanford.edu.

Biomaterials Science
|November 23, 2017
PubMed
Summary
This summary is machine-generated.

Supramolecular crosslinked polymers offer tunable biomaterials with controllable properties. This review explores how crosslink chemistry impacts material dynamics for applications in drug delivery, regenerative medicine, and 3D-bioprinting.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Supramolecular Chemistry

Background:

  • Supramolecular interactions enable the creation of modular and tunable polymeric biomaterials.
  • The dynamics and connectivity of these materials are dictated by the choice of crosslinking chemical moieties.

Purpose of the Study:

  • To review the relationship between supramolecular crosslink chemistry and macroscopic biomaterial properties.
  • To describe the application of these advanced biomaterials in various biomedical fields.

Main Methods:

  • Review of scientific literature on supramolecularly crosslinked polymers.
  • Analysis of how crosslink chemistry influences material properties like responsiveness and viscoelasticity.

Main Results:

  • Supramolecular crosslink chemistry dictates thermodynamic and kinetic parameters, influencing material dynamics.
  • Engineered properties include shear-thinning, self-healing, and controlled cargo release.

Conclusions:

  • Supramolecularly crosslinked polymers are versatile for advanced biomedical applications.
  • Understanding crosslink chemistry is key to tailoring biomaterials for drug delivery, immunology, regenerative medicine, and 3D-bioprinting.