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Cardiac structure and function predicts functional decline in the oldest old.

David Leibowitz1, Jeremy M Jacobs2, Irit Lande-Stessman2

  • 11 Heart Institute, Hebrew University Hadassah Medical School, Israel.

European Journal of Preventive Cardiology
|November 23, 2017
PubMed
Summary
This summary is machine-generated.

Cardiac abnormalities like increased left ventricular mass predict functional decline in older adults. This study shows heart structure impacts daily living activities in the elderly, highlighting the need for cardiac monitoring.

Keywords:
Disabilityechocardiographyleft ventricular functionoldest old

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Area of Science:

  • Gerontology
  • Cardiology
  • Public Health

Background:

  • Investigated the link between cardiac structure/function and activities of daily living (ADL) decline.
  • Focused on an age-homogenous, community-dwelling cohort born 1920-1921.
  • Utilized a five-year follow-up period for assessing functional changes.

Purpose of the Study:

  • To determine if cardiac structure and function predict the deterioration of ADLs.
  • To understand the relationship between echocardiographic findings and functional disability in the oldest old.

Main Methods:

  • Longitudinal cohort study design.
  • Recruited participants from the Jerusalem Longitudinal Cohort Study.
  • Performed home echocardiography and reassessed ADLs after five years.
  • Defined dependence as needing assistance with at least one basic ADL.

Main Results:

  • 362 out of 459 participants (79%) experienced ADL deterioration.
  • Functional decline was associated with higher left ventricular mass index and left atrial volume.
  • Lower ejection fraction was observed in those with functional deterioration.
  • Elevated left ventricular mass index remained a significant predictor in multivariate models.

Conclusions:

  • In the oldest old, cardiac structural abnormalities predict functional disability.
  • Elevated left ventricular mass index, increased left atrial volumes, and systolic dysfunction are key predictors.
  • Diastolic dysfunction was not found to be significantly associated with functional decline in this cohort.