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Updated: Feb 18, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Frailty Is not Associated with Mistreatment
S D Piña-Escudero1, J M A García-Lara, J A Avila-Funes
1José Alberto ÁVILA-FUNES M.D., PhD. Instituto Nacional de Nutrición Salvador Zubirán. Vasco de Quiroga 15. Colonia Belisario Domínguez Sección XVI. Delegación Tlalpan. C.P. 14080, Mexico City, Mexico; e-mail:avilafunes@live.com.mx, Phone number: + 52 (55) 5487 0900, 5703.
Muscle frailty (the condition of being frail) is linked to mistreatment in older adults. However, this association disappears when considering other health issues like disability or depression.
Area of Science:
- Gerontology
- Public Health
- Social Sciences
Background:
- Muscle frailty is a known risk factor for adverse health outcomes and potential social consequences, including mistreatment.
- Understanding the relationship between frailty and mistreatment is crucial for protecting vulnerable older populations.
Purpose of the Study:
- To investigate the association between frailty and mistreatment in community-dwelling older adults aged 70 years and above.
Main Methods:
- A cross-sectional study involving 852 participants.
- Frailty was assessed using the Fried et al. criteria, and mistreatment was identified via the Geriatric Mistreatment Scale.
- Multivariate logistic regression models were employed to analyze the data.
Main Results:
- The prevalence of frailty phenotype was 13.9%, and mistreatment was 20%.
- Unadjusted analysis indicated a significant association between frailty score and mistreatment (OR = 1.16; 95% CI 1.02 to 1.3, p=0.022).
- After adjusting for confounding factors, this association was no longer statistically significant.
Conclusions:
- Frailty, by itself, does not appear to be independently associated with mistreatment in older adults when other geriatric syndromes like disability or depression are present.
- These findings suggest that interventions for mistreatment should consider the complex interplay of multiple geriatric conditions.
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