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Radiation therapy in retroperitoneal sarcoma management.

Rick L Haas1,2, Elizabeth H Baldini3, Peter W Chung4

  • 1Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Journal of Surgical Oncology
|November 23, 2017
PubMed
Summary

Surgery offers a cure for retroperitoneal soft tissue sarcomas (RPS), but local recurrence is a risk. Radiotherapy may help reduce this risk, though level I evidence is needed. Results from a key study are pending.

Keywords:
brachytherapyproton beam therapyradiotherapyretroperitoneal sarcoma

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Primary non-metastatic retroperitoneal soft tissue sarcomas (RPS) are potentially curable with surgery.
  • Patients undergoing surgery for RPS face a significant risk of local recurrence.
  • The role of adjuvant radiotherapy in reducing local recurrence after surgery for RPS is under investigation.

Purpose of the Study:

  • To discuss considerations for radiation oncologists involved in the multidisciplinary treatment of RPS.
  • To highlight the current lack of level I evidence for radiotherapy in RPS management.
  • To provide context for the awaited results of the EORTC-STBSG 62092-22092 trial.

Main Methods:

  • This manuscript is a review and discussion of treatment considerations.
  • It addresses the integration of radiotherapy into the multidisciplinary approach for RPS.
  • It references the ongoing EORTC-STBSG 62092-22092 study.

Main Results:

  • Level I evidence supporting the use of radiotherapy in addition to surgery for RPS is currently lacking.
  • The EORTC-STBSG 62092-22092 study is expected to provide crucial data on this topic.
  • Multidisciplinary discussion is essential for optimal RPS patient management.

Conclusions:

  • While surgery is a primary curative option for RPS, local recurrence remains a concern.
  • The definitive role of radiotherapy in improving outcomes for RPS patients requires further evidence.
  • Radiation oncologists play a vital role in the multidisciplinary care of RPS patients.