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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
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Alpha Oscillations Reduce Temporal Long-Range Dependence in Spontaneous Human Brain Activity.

Robert Becker1, Dimitri Van de Ville2,3, Andreas Kleinschmidt4

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The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 24, 2017
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Alpha oscillations actively regulate long-range dependence (LRD) in brain activity. Increased alpha power shortens LRD, suggesting a mechanism for adaptive control of neural processes.

Keywords:
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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Brain Dynamics

Background:

  • Ongoing neural activity features both oscillations and broadband properties like long-range dependence (LRD).
  • The interaction between these features, particularly alpha oscillations (8-12 Hz) and LRD, is poorly understood.
  • Alpha oscillations are implicated in inhibitory gating, potentially influencing LRD.

Purpose of the Study:

  • To investigate the interaction between alpha oscillations and long-range dependence in ongoing human brain activity.
  • To determine if alpha oscillations modulate the temporal width of LRD in slower brain activity.
  • To explore the regulatory role of alpha oscillations in neural dynamics.

Main Methods:

  • Analysis of two independent resting-state electroencephalography (EEG) and magnetoencephalography (MEG) datasets.
  • Examined the covariation between alpha power and the power slope of slower frequencies (<5 Hz) across space and time.
  • Employed computational modeling to test the hypothesis of alpha-mediated inhibition of baseline activity.

Main Results:

  • Alpha oscillation power significantly covaried with the power slope of frequencies below 5 Hz, indicating that higher alpha power shortened LRD.
  • Temporal precedence of alpha activity changes over slope changes suggested a causal role.
  • A computational model incorporating power-law fluctuations and inhibition of the alpha envelope successfully replicated the empirical findings.

Conclusions:

  • Alpha oscillations serve as an active regulatory mechanism for long-range dependence in slow neural activity.
  • This regulation likely involves inhibitory processes modulated by the alpha rhythm's scale-free properties.
  • Understanding this interaction is crucial for comprehending how brain activity shapes internal states and cognitive functions.