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DNA Vector-based RNA Interference to Study Gene Function in Cancer
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Role of Molecular Biology in Cancer Treatment: A Review Article

Aman Imran1, Hafiza Yasara Qamar1, Qurban Ali1,2

  • 1Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

Iranian Journal of Public Health
|November 24, 2017
PubMed
Abstract

Insights

Cancer arises from genetic mutations, including oncogene activation. Advanced techniques like RNA interference (RNAi), zinc finger nucleases, and CRISPR offer promising cancer treatment strategies for a cancer-free future.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer is fundamentally a genetic disease.
  • It stems from oncogene activation, tumor suppressor gene malfunction, or external mutagenesis.
  • Understanding these genetic underpinnings is crucial for developing effective treatments.

Purpose of the Study:

  • To review current understanding of cancer genetics and molecular mechanisms.
  • To explore advanced molecular techniques for cancer diagnosis and treatment.
  • To highlight future directions in cancer research and therapy.

Main Methods:

  • Literature review of scientific journals (PubMed, Nature, Science Direct, Springer, Elsevier).
  • Analysis of data on oncogene deregulation and its causes.
  • Examination of molecular biology techniques for cancer intervention.

Main Results:

  • Oncogenes are altered proto-oncogenes critical for cell regulation; their dysregulation drives cancer.
  • Gene alterations (translocation, mutation, viral infection) convert proto-oncogenes to oncogenes.
  • Molecular techniques like RNAi can target oncogenes to inhibit cancer cell proliferation.

Conclusions:

  • RNA interference (RNAi), zinc finger nucleases, and CRISPR gene editing show significant promise.
  • These advanced technologies are pivotal for future cancer treatment strategies.
  • They offer a pathway towards achieving a cancer-free world.
Keywords:
CRISPRCancerMutagenesisOncogenesProto-oncogenesTumorViral infection

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