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Updated: Feb 18, 2026
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
A prognostic scoring system using inflammatory response biomarkers in oral cavity squamous cell carcinoma patients
Young Min Park1, Kyung Ho Oh1, Jae-Gu Cho1
1a Department of Otorhinolaryngology-Head and Neck Surgery , Korea University College of Medicine , Seoul , South Korea.
Background:
The aim of this study was to evaluate the effectiveness of a scoring system based on the lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio for predicting disease-specific survival of oral cancer patients treated by surgery.
Methods:
From January 2007 to December 2016, we retrospectively analyzed data from 69 oral cancer patients who received surgery.
Results:
Lymphocyte-to-monocyte ratio was significantly associated with T classification, N classification, and pathologic stage. Neutrophil-to-lymphocyte ratio was significantly associated with T classification and pathologic stage. Platelet-to-lymphocyte ratio was significantly associated with N classification and pathologic stage. In multivariate analysis, only a higher score on this scoring system was significantly associated with poorer disease-specific survival.
Conclusions:
We found that the prognostic score system based on these three values was significantly associated with disease-specific survival of oral cancer patients who received surgery, indicating that the prognostic scoring system was effective in indirectly predicting systemic inflammatory response.
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