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Updated: Feb 18, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
Current and future antenatal management of isolated congenital diaphragmatic hernia
Francesca Maria Russo1, Paolo De Coppi2, Karel Allegaert3
1Academic Department of Development and Regeneration, Clinical Specialties Research Groups, Biomedical Sciences; Clinical Department of Obstetrics and Gynaecology, KU Leuven, Leuven, Belgium.
Abstract:
Congenital diaphragmatic hernia is surgically correctable, yet the poor lung development determines mortality and morbidity. In isolated cases the outcome may be predicted prenatally by medical imaging. Cases with a poor prognosis could be treated before birth. However, prenatal modulation of lung development remains experimental. Fetoscopic endoluminal tracheal occlusion triggers lung growth and is currently being evaluated in a global clinical trial. Prenatal transplacental sildenafil administration may in due course be a therapeutic approach, reducing the occurrence of persistent pulmonary hypertension, either alone or in combination with fetal surgery.
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