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Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from

Jessica Vincent1, Carolina Adura2, Pu Gao3,4

  • 1Vanderbilt University School of Medicine, Nashville, TN, 37027, USA.

Nature Communications
|November 25, 2017
PubMed

Insights

This study corrects previously published data on Fig. 6, ensuring accurate representation of units and IC50 values. The corrections enhance the reliability of research findings related to specific compounds.

Area of Science:

  • Biochemistry
  • Pharmacology

Background:

  • Previous publication contained errors in Figure 6 data representation.
  • Inaccurate units (mM) were used for x-axis and IC50 values in panel h.
  • Specific compounds RU.365, RU.332, and RU.521 were affected by these unit errors.

Purpose of the Study:

  • To correct inaccuracies in Figure 6 of a previously published article.
  • To ensure precise reporting of experimental units and half-maximal inhibitory concentrations (IC50s).
  • To provide accurate data for RU.365, RU.332, and RU.521.

Main Methods:

  • Data re-evaluation of Figure 6, panel h.
  • Correction of x-axis units from millimolar (mM) to micromolar (µM).
  • Adjustment of reported IC50 values from mM to µM for specified compounds.

Main Results:

  • Figure 6, panel h, now displays correct x-axis units as µM.
  • IC50 values for RU.365, RU.332, and RU.521 are accurately reported in µM.
  • Corrected versions are available in both PDF and HTML formats.

Conclusions:

  • The corrected data ensures scientific accuracy and reproducibility.
  • Accurate unit reporting is crucial for interpreting experimental results in pharmacology.
  • Readers should refer to the updated versions for precise information on compound efficacy.

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