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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Related Experiment Video

Updated: Feb 18, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine in Systemic Autoimmune Diseases.

Cinzia Cavestro1, Marcella Ferrero2

  • 1Headache Centre, Department of Neurology, "S.Lazzaro", ASL CN2, Alba, Italy.

Endocrine, Metabolic & Immune Disorders Drug Targets
|November 28, 2017
PubMed
Summary

Migraine and autoimmune diseases like lupus are more common in women. Research suggests a link, with endothelial dysfunction potentially connecting these conditions.

Keywords:
MigraineSjogren's syndromeantiphospholipid syndromeepidemiologyprevalence.rheumatoid arthritissystemic lupus erythematosussystemic sclerosis

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Area of Science:

  • Rheumatology
  • Neurology
  • Epidemiology

Background:

  • Migraine and systemic autoimmune diseases disproportionately affect women.
  • Existing studies suggest a potential association between these conditions.

Purpose of the Study:

  • To review epidemiological data on the association between migraine and systemic autoimmune diseases.
  • To explore potential shared mechanisms linking these conditions.

Main Methods:

  • Literature analysis of Medline articles up to April 2017.
  • Focus on epidemiological studies of migraine with systemic lupus erythematosus, antiphospholipid syndrome, Sjogren's syndrome, and diffuse connective tissue diseases.

Main Results:

  • Migraine, particularly with aura, is more prevalent in systemic lupus erythematosus patients.
  • Associations between migraine and systemic sclerosis, especially with Raynaud's phenomenon and gliotic brain lesions, are reported.
  • Data on antiphospholipid syndrome and migraine are inconclusive, but an association with antiphospholipid carriers is suggested.
  • Population-based studies indicate a higher frequency of systemic autoimmune diseases in migraine sufferers.

Conclusions:

  • Endothelial dysfunction is identified as a potential common underlying mechanism linking autoimmune diseases and migraine.
  • Shared autoimmune alterations may contribute to the co-occurrence of these conditions.