Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

460
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
460
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

355
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
355
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

274
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
274
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

225
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
225
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

638
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
638
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

611
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
611

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obexelimab for the Treatment of IgG4-Related Disease.

The New England journal of medicine·2026
Same author

Diffuse Pruritic Maculopapular Rash With Pitted Necrosis.

JAMA dermatology·2026
Same author

Treatment of severe refractory immune neutropenia with ruxolitinib: Two cases.

Journal of human immunity·2026
Same author

A Patient With Kidney Failure, Polyclonal Hypergammaglobulinemia, and Lymphadenopathy: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Severe Immune Neutropenia Responsive to Ruxolitinib.

EJHaem·2026
Same author

Exercise Volume and Coronary Artery Calcification: A Systematic Review.

CJC open·2026
Same journal

Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

The American journal of the medical sciences·2026
Same journal

In Memoriam: Maurice A. Mufson, MD, MACP.

The American journal of the medical sciences·2026
Same journal

Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

The American journal of the medical sciences·2026
Same journal

Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

The American journal of the medical sciences·2026
Same journal

Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

The American journal of the medical sciences·2026
Same journal

The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

The American journal of the medical sciences·2026
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.5K

Eosinophilic Myocarditis.

Christopher C Cheung1, Maggie Constantine2, Amir Ahmadi1

  • 1Division of Cardiology, University of British Columbia, Vancouver, British Columbia.

The American Journal of the Medical Sciences
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

Persistent eosinophilia can lead to eosinophilic myocarditis, a serious heart condition. Accurate diagnosis of the cause is crucial for effective treatment, ranging from targeted therapies to steroids and novel agents.

Keywords:
EosinophiliaMyocarditisReview

More Related Videos

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.5K
Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
06:49

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Published on: May 31, 2017

8.2K

Related Experiment Videos

Last Updated: Feb 18, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.5K
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.5K
Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
06:49

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy

Published on: May 31, 2017

8.2K

Area of Science:

  • Cardiology
  • Hematology
  • Immunology

Background:

  • Persistent eosinophilia can cause eosinophilic myocarditis, leading to cardiac tissue damage.
  • Eosinophilic myocarditis presents a spectrum from mild to severe, involving necrosis, thrombosis, and fibrosis.
  • Accurate diagnosis is essential as systemic treatment depends on the underlying cause.

Purpose of the Study:

  • To outline the diagnostic evaluation for persistent eosinophilia and its cardiac manifestations.
  • To detail the treatment strategies for various causes of eosinophilic myocarditis.
  • To highlight the importance of precise diagnosis in managing eosinophilic myocarditis.

Main Methods:

  • Assessment for reactive causes: vasculitis, infections, autoimmune diseases, IgG4-related disease, medications.
  • Identification of genetic lesions for clonal myeloid disorders (PDGFRA, PDGFRB, FGFR1).
  • Flow cytometry and molecular studies for lymphocyte-variant hypereosinophilic syndrome (HES).

Main Results:

  • Reactive eosinophilia requires treatment of the underlying condition (e.g., antiparasitics, immunosuppressants).
  • Clonal myeloid disorders often respond to tyrosine kinase inhibitors like imatinib.
  • Idiopathic HES and lymphocyte-variant HES are primarily treated with steroids, with hydroxyurea or interferon-alpha for refractory cases.

Conclusions:

  • Thorough investigation is paramount for diagnosing the cause of eosinophilic myocarditis.
  • Treatment approaches are tailored to the specific etiology, including targeted therapies and immunosuppression.
  • Mepolizumab shows promise as a steroid-sparing agent for HES, though availability is limited.