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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Acute Kidney Injury: It's not just the 'big' burns.
L A Kimmel1, S Wilson2, R G Walker3
1Department of Physiotherapy, The Alfred, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
Injury
|November 28, 2017
Summary
Acute Kidney Injury (AKI) affects 15% of burn patients with 10-19% TBSA, with age being a key factor. AKI in burn patients is linked to longer hospital stays, highlighting the need for risk reduction strategies.
Area of Science:
- Nephrology
- Trauma Surgery
- Burn Care
Background:
- Acute Kidney Injury (AKI) is a significant complication in severe burn patients, affecting over 25% and leading to long-term issues.
- Research on AKI in burn patients primarily focuses on severe burns (%TBSA > 19%), leaving a gap in understanding AKI development in moderate burns (10-19% TBSA).
Purpose of the Study:
- To determine the incidence of AKI in burn patients with %TBSA ≥ 10.
- To identify factors associated with AKI development in this patient group.
- To explore the relationship between AKI and hospital metrics like length of stay (LOS).
Main Methods:
- A retrospective review of medical records for burn patients admitted to a major adult burns center.
- Data collected included demographics, injury details, and AKI incidence using RIFLE criteria.
- Multiple logistic regression was used to identify factors associated with AKI.
Main Results:
- AKI incidence was 22.5% overall, with 15% in the 10-19% TBSA group.
- Factors associated with AKI included increasing age, %TBSA, number of surgeries, and cardiac comorbidity.
- All patients with a renal comorbidity developed AKI, and AKI was associated with longer hospital stays.
Conclusions:
- This study is the first to demonstrate an association between moderate burns (10-19% TBSA) and AKI.
- AKI in burn patients is linked to adverse outcomes, including prolonged hospitalization.
- Further prospective research is crucial for understanding and mitigating AKI risk in burn patients.
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