Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

605
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
605
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

539
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
539
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

375
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
375
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

611
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
611

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amide Hydrogen-Deuterium Exchange in Isotopically Mixed Water.

ACS physical chemistry Au·2026
Same author

Intrinsic Hydrogen-Deuterium Exchange Rates in H<sub>2</sub>O/D<sub>2</sub>O Mixtures.

The journal of physical chemistry. B·2026
Same author

Rescue Surgery for Advanced Stage Lung Cancer: A Systematic Review.

Thoracic cancer·2025
Same author

Combined biochemical profiling and DNA sequencing in the expanded newborn screening for inherited metabolic diseases: the experience in an Italian reference center.

Orphanet journal of rare diseases·2025
Same author

Computational Tools for Hydrogen-Deuterium Exchange Mass Spectrometry Data Analysis.

Chemical reviews·2024
Same author

Covid-19 in cystic fibrosis patients compared to the general population: Severity and virus-host cell interactions.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2024

Related Experiment Video

Updated: Feb 18, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

17.2K

Cardiac cachexia in sub-Saharan Africa.

Antonio Grimaldi1, Annalisa De Concilio2, Luca Marsero3

  • 1St. Mary's Lacor Hospital, Gulu, Uganda; San Raffaele Scientific Institute, Università Vita-Salute, Milan, Italy; St Raphael of St Francis, Nsambya Hospital, Kampala, Uganda.

Indian Heart Journal
|November 28, 2017
PubMed
Summary

Cachexia, a global health issue, is underdiagnosed in sub-Saharan Africa. This report highlights cardiac cachexia in Uganda, emphasizing its neglect and impact on patient quality of life.

More Related Videos

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.7K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

14.0K

Related Experiment Videos

Last Updated: Feb 18, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

17.2K
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.7K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

14.0K

Area of Science:

  • Cardiology
  • Public Health
  • Internal Medicine

Background:

  • Cachexia presents a significant global health challenge, yet prevalence data from developing nations remain limited.
  • In sub-Saharan Africa, wasting syndromes are commonly linked to infectious diseases like malaria, HIV, and tuberculosis, as well as end-stage heart disease, all contributing to high mortality and reduced quality of life.

Observation:

  • This report details two distinct cases of cardiac cachexia in Uganda, stemming from end-stage heart disease.
  • The significant age disparity between the patients illustrates the varied impact of healthcare services across Uganda's diverse settings, from rural areas to urban centers undergoing epidemiological transition.

Findings:

  • The observed wasting syndrome in both patients underscores that cachexia is frequently overlooked and underestimated in many sub-Saharan African countries.
  • Cardiac cachexia, specifically, appears to be a significant but under-recognized contributor to morbidity and mortality in the region.

Implications:

  • There is a critical need for increased awareness and improved diagnostic strategies for cachexia, particularly cardiac cachexia, in sub-Saharan Africa.
  • Addressing cachexia in this region requires tailored public health interventions that consider the unique epidemiological and resource contexts.