Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

10.1K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
10.1K
What is the Immune System?01:38

What is the Immune System?

133.5K
Overview
133.5K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.6K
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

18.0K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
18.0K
Inflammation01:38

Inflammation

62.6K
Overview
62.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.4K
Overview
84.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

cGAS/STING sensing in dendritic cells discriminates between daptomycin sensitive and resistant <i>Staphylococcus aureus</i> clinical isolates.

iScience·2026
Same author

Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages.

EMBO reports·2026
Same author

Scaling and quantization of large-scale foundation model enables resource-efficient predictions in network biology.

Nature computational science·2026
Same author

Neighborhood nonnegative matrix factorization identifies patterns and spatially-variable genes in large-scale spatial transcriptomics data.

Genome biology·2026
Same author

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics.

eLife·2025
Same author

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor.

Nature immunology·2025
Same journal

Nanotechnology-Stem Cell Strategies in 3D Glioblastoma Organoid: Targeting Glioma Stem Cells Within a Complex Tumor Microenvironment.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
12:47

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

12.2K

Emerging Concepts in Innate Immunity.

Karin Pelka1, Dominic De Nardo2,3

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

Methods in Molecular Biology (Clifton, N.J.)
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

This review covers new innate immunity findings, including Gasdermin D in pyroptosis and immune signaling. It explores host-microbiome interactions and innate immune memory, highlighting CRISPR/Cas9

Keywords:
ASCCRISPR/Cas9CaspaseCell deathGasdermin DInnate immune memoryInnate immunityMAVSMyddosomePRRsPyroptosiscGAS

More Related Videos

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

11.0K
Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

9.3K

Related Experiment Videos

Last Updated: Feb 18, 2026

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
12:47

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

12.2K
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

11.0K
Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

9.3K

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Innate immunity is the first line of defense against pathogens.
  • Understanding innate immune signaling is crucial for developing new therapies.

Purpose of the Study:

  • To review recent advances in innate immunity.
  • To highlight key discoveries and future directions in the field.

Main Methods:

  • Literature review of recent findings in innate immunity.
  • Discussion of emerging technologies like CRISPR/Cas9.

Main Results:

  • Discovery of Gasdermin D as an initiator of pyroptosis.
  • Elucidation of inflammatory caspases in immune signaling.
  • Insights into signalosome formation, cellular homeostasis, metabolism, and cell-cell communication.
  • Exploration of host-microbiome interplay and innate immunological memory.

Conclusions:

  • Recent discoveries have significantly advanced our understanding of innate immunity.
  • Technological innovations, such as CRISPR/Cas9, are poised to address outstanding questions.