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Updated: Aug 17, 2026

The Mouse Isolated Perfused Kidney Technique
Published on: November 17, 2016
Ultrastructure of Rat Kidneys after Intravenous Administration of Modified Magnetite Nanoparticles
I V Mil'to1,2, I V Sukhodolo3, V V Ivanova3
1Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation, Tomsk, Russia. milto_bio@mail.ru.
Abstract:
The ultrastructure of nephrocytes of the proximal and distal convoluted tubules, podocytes, mesangial cells, and macrophages of the interstitial connective tissue was studied after single intravenous administration of magnetite nanoparticles modified with chitosan (magnetic nanospheres) or lipids (magnetic liposomes). Transmission electron microscopy showed ultrastructural features of absorption of magnetite nanoparticles. The shape, size, and number of vesicles containing nanoparticles in nephrocytes of convoluted tubules and macrophages after administration of the suspensions of magnetic nanospheres and magnetic liposomes were described.

