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Related Concept Videos

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Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Related Experiment Video

Updated: Feb 18, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

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[Bone remodeling through a phosphate metabolism.]

Takeshi Miyamoto1

  • 1Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.

Clinical Calcium
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

Enpp1 plays a crucial role in maintaining phosphate homeostasis by regulating the FGF23-Klotho-vitamin D axis. Understanding this pathway is key to addressing diseases like hypophosphatemic rickets.

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Mineral Metabolism

Background:

  • Phosphorus is vital for bone health, and its metabolic dysregulation causes diseases like hypophosphatemic rickets.
  • Phosphate homeostasis is maintained by intestinal absorption, renal reabsorption, and hormonal regulation.
  • The FGF23-Klotho-vitamin D axis is a key regulatory pathway for phosphate balance.

Purpose of the Study:

  • To review the role of Enpp1 in the FGF23-Klotho-vitamin D axis.
  • To discuss the implications of Enpp1 in bone health and phosphate metabolism.

Main Methods:

  • Literature review of studies on Enpp1, FGF23, Klotho, and vitamin D.
  • Analysis of the molecular mechanisms regulating phosphate homeostasis.

Main Results:

  • Enpp1 is a critical regulator within the FGF23-Klotho-vitamin D signaling pathway.
  • Dysfunction in this axis, potentially involving Enpp1, contributes to phosphate imbalances and related diseases.

Conclusions:

  • Enpp1 is integral to maintaining skeletal integrity and phosphate balance.
  • Targeting the Enpp1-mediated pathway may offer therapeutic strategies for metabolic bone diseases.