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Updated: Feb 18, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
Published on: June 16, 2022
[Regulation of bone remodeling by anti-resorptives.]
1Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
Abstract:
Classical anti-resorptives such as bisphosphonates inhibit remodeling, leading to decreases in both bone resorption and formation markers. Changes in these markers are useful in predicting future bone mineral density and fracture risk to some extent. More recently developed drugs such as denosumab and odanacatib, which also fall into the category of anti-resorptives, show unique effects on modeling and remodeling. This overview summarizes action of anti-resorptives from a viewpoint of remodeling.
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