[Reduced uptake of 99mTc methylenediphosphonate by bone irradiated for neoplastic lesions]

Some cases of more or less evident reduction in 99mTc MDP take-up by bone subjected to cobalt therapy for skeletal and extraskeletal neoplastic diseases are presented. On the basis of acquired experience, stress is laid on the diagnostic and prognostic importance of correct assessment of bone scintigraphic changes after irradiation treatment. Some pathogenetic theories in this phenomenon are discussed.