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Updated: Feb 18, 2026
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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
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HPV vaccination of immunocompromised hosts
S M Garland1, J M L Brotherton2, A B Moscicki3
1Department of Microbiology and Infectious Diseases, Royal Women's Hospital, 30 Flemington Road, Parkville 3052, Australia; Murdoch Childrens Research Institute, 50 Flemington Road, Parkville 3052, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville 3052, Australia.
Papillomavirus Research (Amsterdam, Netherlands)
|November 29, 2017
Summary
Immunocompromised individuals face higher risks of human papillomavirus (HPV) diseases. Prophylactic HPV vaccines are safe and effective in this population, requiring a 3-dose regimen per national guidelines.
Area of Science:
- Immunology
- Vaccinology
- Oncology
Background:
- Immunocompromised individuals exhibit elevated susceptibility to human papillomavirus (HPV) infections and associated diseases.
- Established data confirm increased HPV-related morbidity in immunocompetent versus immunocompromised populations.
Purpose of the Study:
- To evaluate the safety and immunogenicity of prophylactic HPV sub-unit vaccines in immunocompromised populations.
- To provide recommendations for HPV vaccination strategies in immunocompromised individuals.
Main Methods:
- Review of existing literature on HPV vaccine efficacy and safety in immunocompromised cohorts.
- Analysis of national guidelines regarding vaccination schedules for at-risk populations.
Main Results:
- Prophylactic HPV sub-unit vaccines demonstrate favorable safety and immunogenicity profiles in immunocompromised individuals.
- Vaccination adherence to national guidelines is strongly recommended.
Conclusions:
- HPV vaccination is a critical preventive measure for immunocompromised individuals.
- A 3-dose regimen is recommended for optimal protection when administering HPV vaccines to immunocompromised populations.
Keywords:
HPV GuidelinesHPV related cancersHuman papillomavirus (HPV)Immunocompromised hostsVaccinationMore Related Videos
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