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Behavioral Interventions to Prevent or Delay Dementia: Protocol for a Randomized Comparative Effectiveness Study.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Clinical Research

Background:

  • Individuals at risk for dementia and their caregivers face challenges in selecting effective behavioral interventions.
  • There is a need to identify empirically supported interventions that significantly impact patient and caregiver outcomes.

Purpose of the Study:

  • To determine which empirically supported behavioral interventions provide the greatest benefit for patients with mild cognitive impairment (MCI) and their partners.
  • To assess the impact of interventions on highly valued outcomes such as quality of life and self-efficacy.

Main Methods:

  • A comparative effectiveness trial involving 300 participants with MCI and their study partners.
  • Five behavioral interventions (yoga, memory compensation training, computerized cognitive training, support groups, wellness education) were evaluated.
  • A unique 10-day multicomponent intervention design where one intervention was withheld for each couple.

Main Results:

  • Enrollment is complete with 272 couples participating in the trial.
  • Longitudinal follow-up assessments are ongoing at multiple time points (end-of-intervention, 6, 12, 18 months).
  • Primary and secondary outcomes are anticipated to be reported within the next two years.

Conclusions:

  • The study protocol outlines a randomized comparative effectiveness design to evaluate behavioral interventions for dementia prevention or delay.
  • The trial's rationale, design, power analysis, and analysis plan are detailed.
  • Enrollment data is presented, with follow-up phases currently underway.