Related Experiment Video

Updated: Feb 17, 2026

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System
05:45

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

Published on: January 9, 2020

8.4K

Rodent Papillomaviruses

Aayushi Uberoi1, Paul F Lambert2

  • 1McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI 53705, USA. aayushi.uberoi@wisc.edu.

Viruses
|December 1, 2017
PubMed

Insights

Rodent papillomaviruses, like MmuPV1 in mice, offer valuable preclinical models for studying Human Papillomavirus (HPV) skin cancers. These underutilized models advance our understanding of HPV biology and disease progression.

Area of Science:

  • Virology
  • Oncology
  • Infectious Diseases

Background:

  • Preclinical infection models are crucial for understanding Human Papillomavirus (HPV) biology and disease.
  • Rodent papillomaviruses (PVs) and their models are underutilized yet valuable resources.
  • Cutaneous papillomaviruses are frequently associated with HPV-related skin cancers.

Purpose of the Study:

  • To review the current knowledge of PV biology gained from studying rodent papillomaviruses.
  • To highlight research gaps and opportunities in rodent PV model systems.
  • To emphasize the utility of MmuPV1 as a model for cutaneous papillomaviruses.

Main Methods:

  • Review of existing literature on rodent papillomaviruses (MnPV1 and MmuPV1).
  • Analysis of MmuPV1 as a model for studying papillomavirus pathogenesis.
  • Identification of knowledge gaps in rodent PV biology.

Main Results:

  • MmuPV1 naturally infects laboratory mice, making it a highly accessible model.
  • Both MnPV1 and MmuPV1 cause skin malignancies, mimicking human cutaneous PV infections.
  • Rodent PV models offer insights into HPV pathogenesis and skin cancer development.

Conclusions:

  • Rodent papillomaviruses, particularly MmuPV1 in mice, represent powerful, yet underutilized, models for HPV research.
  • Further investigation of these models can significantly advance the understanding of HPV-related skin cancers.
  • MmuPV1's genetic modifiability and natural infection in lab mice present unique research opportunities.
Keywords:
murine papillomaviruspapillomavirusespreclinical modelsrodent papillomaviruses

More Related Videos

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses06:13

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

Published on: November 24, 2014

9.9K
Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses08:10

Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses

Published on: May 2, 2019

8.9K

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.4K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
868
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.0K
Viruses of Archaea01:29

Viruses of Archaea

Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
541
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
15.0K