Related Experiment Video
Updated: Feb 17, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Dosing strategies to optimize currently available anti-MRSA treatment options (Part 2: PO options)
Kenna D Payne1, Amrita Das2, Michelle Ndiulor2
1a Pharmacy Practice Department , Texas Tech University Health Sciences Center , Amarillo , TX , USA.
Introduction:
Methicillin-resistant Staphylococcus aureus (MRSA) is a problematic pathogen in both outpatient and inpatient settings. Research to optimize the dosing of these agents is needed to slow the development of antimicrobial resistance and to decrease the likelihood of clinical failure. Areas covered: This review summarizes the available data for orally administered antimicrobials routinely used as monotherapy for MRSA infections. We make recommendations and highlight the current gaps in the literature. A PubMed (1966 - Present) search was performed to identify relevant literature for this review. Expert commentary: There is a vast divide in the amount of pharmacokinetic/pharmacodynamic data to guide dosing decisions for older MRSA agents compared with the oxazolidenones. Five-year view: Additional retrospective data will become available for the older MRSA agents in severe MRSA infections.
Related Concept Videos
Dosage Regimen: Multiple Oral Dosage
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Dosage Interval and Administration Route: Determination Methods
Dosage Regimens: Designs and Approaches
Drug Dosage Regimen: Overview
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

