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Updated: Feb 17, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
COGcollator: a web server for analysis of distant relationships between homologous protein families
Daria V Dibrova1, Kirill A Konovalov2, Vadim V Perekhvatov3
1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia. udavdasha@belozersky.msu.ru.
Background:
The Clusters of Orthologous Groups (COGs) of proteins systematize evolutionary related proteins into specific groups with similar functions. However, the available databases do not provide means to assess the extent of similarity between the COGs.
Aim:
We intended to provide a method for identification and visualization of evolutionary relationships between the COGs, as well as a respective web server.
Results:
Here we introduce the COGcollator, a web tool for identification of evolutionarily related COGs and their further analysis. We demonstrate the utility of this tool by identifying the COGs that contain distant homologs of (i) the catalytic subunit of bacterial rotary membrane ATP synthases and (ii) the DNA/RNA helicases of the superfamily 1.
Reviewers:
This article was reviewed by Drs. Igor N. Berezovsky, Igor Zhulin and Yuri Wolf.
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