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Updated: Feb 17, 2026
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
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Recent advances in understanding bile acid homeostasis
1Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, USA.
F1000Research
|December 1, 2017
Summary
Bile acids, cholesterol metabolites, act as signaling molecules regulating metabolic homeostasis. This review explores advances in bile acid signaling, synthesis, and gut microbiome interactions for maintaining homeostasis.
Area of Science:
- Biochemistry
- Endocrinology
- Microbiology
Background:
- Bile acids are cholesterol derivatives crucial for nutrient absorption and cholesterol excretion.
- Emerging roles of bile acids as signaling molecules activating FXR and TGR5.
- Bile acid homeostasis is maintained by complex regulatory mechanisms.
Purpose of the Study:
- To review recent advancements in bile acid signaling pathways.
- To discuss emerging concepts in bile acid synthesis and regulation.
- To explore the role of the gut microbiome in bile acid homeostasis.
Main Methods:
- Literature review of recent studies on bile acid signaling.
- Analysis of classic and alternative bile acid synthesis pathways.
- Investigation of intestinal bile acid signaling and gut microbiome interactions.
Main Results:
- Bile acids signal through nuclear (FXR) and membrane (TGR5) receptors.
- Complex feedback and feedforward mechanisms regulate bile acid homeostasis.
- Gut microbiome significantly influences bile acid metabolism and signaling.
Conclusions:
- Bile acid signaling is vital for metabolic homeostasis and tissue protection.
- Understanding bile acid synthesis and regulation is key to managing metabolic diseases.
- The gut microbiome plays a critical role in maintaining bile acid balance.
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