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Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity

Gongpu Lan1, Manmohan Singh2, Kirill V Larin2,3

  • 1School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.

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|December 1, 2017
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Summary

Common-path phase-sensitive optical coherence elastography (PhS-OCE) significantly improves soft-tissue biomechanical property quantification. This advanced technique enhances displacement sensitivity and phase stability for more precise imaging.

Keywords:
(110.4500) Optical coherence tomography(120.4570) Optical design of instruments(120.5050) Phase measurement(120.7280) Vibration analysis; Elastography(170.3880) Medical and biological imaging

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Area of Science:

  • Biomedical Optics
  • Biophysics
  • Medical Imaging

Background:

  • Phase-sensitive optical coherence elastography (PhS-OCE) quantifies soft-tissue biomechanics.
  • Conventional PhS-OCE faces challenges with optical phase stability and displacement sensitivity.

Purpose of the Study:

  • To implement a common-path OCT design for enhanced PhS-OCE.
  • To improve dynamic elastography imaging by increasing displacement sensitivity and optical phase stability.

Main Methods:

  • Utilized a common-path OCT design for PhS-OCE.
  • Measured background phase stability and surface displacement variation.
  • Estimated Young's modulus for tissue phantoms.

Main Results:

  • Common-path PhS-OCE demonstrated superior background phase stability (0.24 ± 0.07nm) compared to conventional PhS-OCE (1.60 ± 0.11μm).
  • Coefficient of variation for displacement measurements was significantly lower (2%) in common-path PhS-OCE versus conventional (11%).
  • Precise Young's modulus estimates were obtained for agar tissue phantoms (e.g., 24.96 ± 2.18kPa for 1% agar).

Conclusions:

  • Common-path PhS-OCE effectively minimizes background optical phase instability to sub-nanometer levels.
  • This advancement offers a larger dynamic detection range and higher sensitivity for surface displacement measurements.
  • The improved common-path PhS-OCE enhances the quantification of soft-tissue biomechanical properties.