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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Feb 17, 2026

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

New developments in immunotherapy for pediatric solid tumors.

Liora M Schultz¹, Robbie Majzner¹, Kara L Davis¹

¹Department of Pediatrics.

Current Opinion in Pediatrics

|December 1, 2017

Summary

This summary is machine-generated.

Immunotherapy shows promise for pediatric solid tumors, with antibody-based treatments like chimeric antigen receptors (CARs) and checkpoint blockade being investigated. Further research aims to improve efficacy in these challenging cancers.

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Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

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Area of Science:

Oncology
Immunology
Pediatric Medicine

Background:

Advanced pediatric solid tumors have poor prognoses, necessitating novel therapeutic approaches.
Immunotherapy strategies are being developed to improve outcomes in specific pediatric cancer subsets.

Purpose of the Study:

To review recent advancements in immunotherapy for pediatric solid tumors.
To discuss the application of monoclonal antibodies (mAbs) and related therapies, including checkpoint blockade and chimeric antigen receptors (CARs).

Main Methods:

Review of preclinical and clinical data on mAb-based immunotherapies.
Focus on therapies targeting GD2, checkpoint inhibitors, and CAR T-cell therapies.
Exploration of novel strategies like antibody-drug conjugates, bispecific antibodies, and intratumoral administration.

Main Results:

The most compelling pediatric solid tumor mAb experience involves targeting GD2 for neuroblastoma.
CAR T-cell therapies in pediatric solid tumors have not yet matched responses seen in hematologic malignancies.
Single-agent checkpoint blockade has shown limited therapeutic effect in pediatric solid tumors; combinatorial strategies show promise.

Conclusions:

Pediatric immunotherapy for solid tumors is in the early stages of clinical translation.
Advanced technologies and novel strategies are expected to enhance the efficacy of immunotherapy in pediatric solid tumors.