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Visual Evoked Potentials in Glaucoma and Alzheimer's Disease
Elisa Cerri1, Carlotta Fabiani1, Chiara Criscuolo1
1Neuroscience Institute of the National Council of Research (CNR), Via G. Moruzzi 1, Pisa, 56100, Italy.
Methods in Molecular Biology (Clifton, N.J.)
|December 1, 2017
Summary
This study examines visual responses in animal models of glaucoma and Alzheimer's disease (AD). Simultaneous recording of pattern electroretinogram (P-ERG) and visual evoked cortical potentials (VEPs) helps identify neurodegeneration sites.
Area of Science:
- Neuroscience
- Ophthalmology
- Neurology
Background:
- Visual responses to contrast gratings are crucial for understanding visual processing.
- Pattern electroretinogram (P-ERG) and visual evoked cortical potentials (VEPs) are vital for localizing neurodegeneration.
- Glaucoma and Alzheimer's disease (AD) are progressive neurodegenerative conditions affecting the elderly.
Purpose of the Study:
- To characterize the parametric properties of visual evoked responses in animal models of glaucoma and Alzheimer's disease.
- To establish a methodology for simultaneously recording P-ERG and VEPs in these models.
Main Methods:
- Utilized animal models of glaucoma and Alzheimer's disease.
- Recorded pattern electroretinogram (P-ERG) and visual evoked cortical potentials (VEPs) simultaneously.
- Analyzed parametric properties of visual evoked responses to alternating contrast gratings.
Main Results:
- Presented detailed parametric properties of visual evoked responses in glaucoma and AD models.
- Demonstrated the utility of combined P-ERG and VEP recordings for assessing neurodegeneration.
- Established a foundation for further research into disease mechanisms and therapeutic interventions.
Conclusions:
- Simultaneous P-ERG and VEP recordings provide a comprehensive assessment of visual pathway integrity in neurodegenerative disease models.
- This approach is essential for differentiating retinal and post-retinal contributions to visual dysfunction in glaucoma and AD.
- The findings support the use of these animal models for studying neurodegenerative diseases affecting vision.
Keywords:
BiomarkersNeurodegenerationsPattern electroretinogram (P-ERG)Visual cortical evoked potentials (VEPs)Visual systemMore Related Videos
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