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Serum ferritin and primary lung cancer
Zhongqing Chen1, Bo Zhu1, Chao Ou2
1Department of Clinical Laboratory, Guangxi Medical University Affiliated Tumor Hospital, Nanning 530021, Guangxi Province, P.R. China.
Oncotarget
|December 2, 2017
Summary
Serum ferritin (SF) levels in lung cancer patients show complex relationships with iron status. SF and transferrin (TRF) correlated with T stage in males, while SF correlated with menopausal status in females, indicating varied regulation.
Area of Science:
- Oncology
- Hematology
- Biochemistry
Background:
- Conflicting research exists on the relationship between iron deficiency and high serum ferritin (SF) in primary lung cancer patients.
- Understanding iron metabolism markers like SF, hemoglobin (Hb), and transferrin (TRF) is crucial for lung cancer patient management.
Purpose of the Study:
- To investigate the concentrations of SF, Hb, and TRF in primary lung cancer patients.
- To analyze the correlation of these markers with clinical and demographic factors, including gender, smoking status, menopausal status, pathological type, stage, and TNM stage.
Main Methods:
- Cross-sectional study involving 569 male and 252 female primary lung cancer patients.
- Measurement of serum ferritin (SF), hemoglobin (Hb), and transferrin (TRF) levels.
- Statistical analysis to correlate marker levels with patient subgroups based on gender, smoking, menopausal status, pathology, and stage.
Main Results:
- In male patients, SF and TRF levels correlated significantly with T stage (p<0.01).
- In female patients, SF and TRF levels correlated significantly with menopausal status (p<0.01).
- Hemoglobin (Hb) levels correlated with smoking status, pathological type, stage, and TNM stages in males (p<0.01), but not in females (p>0.05).
Conclusions:
- Serum ferritin levels may be regulated by different mechanisms in different patient populations.
- The physiological significance of SF may vary based on gender, menopausal status, and cancer progression.
- Further research is needed to elucidate the complex role of iron metabolism markers in lung cancer.
