Related Experiment Video

Updated: Feb 17, 2026

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition
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Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

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Evolving Areas in Heart Transplantation

Brittany N Weber1, Jon A Kobashigawa2, Michael M Givertz1

  • 1Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

JACC. Heart Failure
|December 2, 2017
PubMed

Insights

Heart transplantation has evolved significantly over 50 years, improving surgical techniques and patient care. Future advancements include xenotransplantation, stem cells, and artificial hearts for cardiac replacement therapy.

Area of Science:

  • Cardiology
  • Transplant Surgery
  • Immunology

Background:

  • The first human-to-human heart transplant occurred in 1967, marking a milestone in cardiac surgery.
  • Significant advancements have since transformed heart transplantation practices.

Purpose of the Study:

  • To provide a perspective on the evolution of heart transplantation.
  • To highlight key advancements and future directions in cardiac replacement therapy.

Main Methods:

  • Review of historical progress in heart transplantation.
  • Discussion of current and emerging cardiac replacement therapies.

Main Results:

  • Progress in surgical techniques, immunosuppression, donor/recipient selection, and post-transplant care.
  • Key areas of focus include rejection screening, cardiac allograft vasculopathy, and novel therapies.

Conclusions:

  • Heart transplantation has undergone remarkable transformation over five decades.
  • Future innovations like xenotransplantation, stem cells, tissue engineering, and total artificial hearts promise further advancements in cardiac replacement.

Keywords:
cardiac allograft vasculopathyheart transplantationimmunosuppressionstem cellstissue engineeringtransplant rejection

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