Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

17
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
17
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

286
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
286
Drug Therapy01:28

Drug Therapy

315
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
315
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

35
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
35
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

24
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
24
Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

497
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
497

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are antidepressants overprescribed? Yes, they still are.

BMJ (Clinical research ed.)·2026
Same author

Medicine is cooked.

BMJ (Clinical research ed.)·2026
Same author

Covid-19 in Sweden and the UK: Risk, the Game of Life.

BMJ (Clinical research ed.)·2020
Same author

Des Spence: Why #healthbeliefs should be top of all our communications.

BMJ (Clinical research ed.)·2020
Same author

Bad Medicine: Nofreelunch.

The British journal of general practice : the journal of the Royal College of General Practitioners·2019
Same author

Bad Medicine: Rest in peace.

The British journal of general practice : the journal of the Royal College of General Practitioners·2019
Same journal

Evaluating Additional Roles in Primary Care: Expanding Capacity and Transforming Care Delivery.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same journal

Impact of local enhanced incentive schemes on the performance of general practices within the United Kingdom: a systematic review.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same journal

Learning disability register enrolment in young people in England: Cohort Study, 2015-2023.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same journal

Disparities in the uptake of learning disability (intellectual disability) annual health checks.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same journal

Recording of Pharmacy First consultations in general practice records in England: an observational study of the service's first year using OpenSAFELY.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same journal

"I have no idea who does the bone thing" A qualitative exploration of older women and healthcare professionals' experiences to guide improvements in osteoporosis care.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
See all related articles

Related Experiment Video

Updated: Feb 17, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

19.6K

Bad Medicine: Polypharmacy

Des Spence1

  • 1Maryhill Health Centre, Glasgow.

The British Journal of General Practice : the Journal of the Royal College of General Practitioners
|December 2, 2017
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.5K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.5K

Related Experiment Videos

Last Updated: Feb 17, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

19.6K
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.5K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.5K