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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
[Current dilemmas on the transmission of hepatitis E virus]
E de Weerd-de Jong1, A M Peters, J C Rahamat-Langendoen
1Radboudumc, Nijmegen.
Immunocompromised patients face high risks from Hepatitis E virus (HEV) infection, potentially leading to severe liver disease. Preventing HEV transmission, including through blood products, is crucial for this vulnerable population.
Area of Science:
- Hepatology
- Infectious Diseases
- Immunology
Background:
- Immunocompromised patients, particularly transplant recipients, are highly susceptible to chronic Hepatitis E virus (HEV) infection.
- Chronic HEV can cause progressive liver disease, cirrhosis, and complications related to reduced immunosuppression, such as graft rejection.
Observation:
- The Dutch National Institute for Public Health and the Environment (RIVM) alerted transplant patients to HEV risks from contaminated pork products.
- A Dutch blood bank initiated HEV screening of blood products to prevent iatrogenic transmission.
Findings:
- Two cases of HEV infection in immunocompromised patients are presented.
- The study highlights significant risks of HEV infection and transmission in this population.
Implications:
- Preventing HEV transmission, including via transfusion, is essential to mitigate severe health outcomes in immunocompromised individuals.
- Enhanced surveillance and preventative measures are critical for managing HEV in vulnerable patient groups.
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