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Pituitary adenoma with multiple ciliated cysts: transitional cell tumor?
S Nakasu1, Y Nakasu, K Kyoshima
1Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan.
Surgical Neurology
|January 1, 1989
Summary
This study details a rare prolactin-secreting pituitary tumor with cysts. The cyst lining cells shared features with Rathke
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Pituitary tumors, particularly prolactinomas, are common.
- Cystic changes within pituitary adenomas can occur but are less frequent.
- Understanding the cellular origin and characteristics of cystic pituitary adenomas is crucial for diagnosis and treatment.
Observation:
- A case of a prolactin-secreting pituitary tumor exhibiting extensive multiple cyst formation is presented.
- Ultrastructural analysis revealed cyst-lining cells with cilia, secretory granules, and absence of a basal lamina, resembling Rathke's cleft cyst cells.
- Immunohistochemical staining identified adenoma cells secreting both prolactin and growth hormone, while lining cells were cytokeratin-positive.
Findings:
- The pituitary adenoma contained both prolactin-secreting and growth hormone-secreting cells.
- Cyst-lining cells displayed characteristics of Rathke's cleft cyst but lacked a basal lamina and contained secretory granules.
- Cytokeratin positivity in lining cells and absence of S-100 protein provided further cellular characterization.
Implications:
- This case expands the understanding of pituitary tumor heterogeneity and cystic presentations.
- The findings suggest a potential relationship or shared origin between certain pituitary adenomas and Rathke's cleft cysts.
- Further research into the pathogenesis of cystic pituitary adenomas is warranted for improved clinical management.