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Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials.
Kiara F Bruggeman1, Richard J Williams2,3, David R Nisbet1,3
1Laboratory of Advanced Biomaterials, Research School of Engineering, The Australian National University, Canberra, ACT, 2601, Australia.
Advanced Healthcare Materials
|December 2, 2017
Summary
Tissue engineering scaffolds support tissue regeneration by mimicking the extracellular matrix. Advanced scaffolds integrate drug delivery systems for enhanced regenerative medicine outcomes.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Tissue engineering scaffolds mimic the extracellular matrix for regenerative medicine.
- Next-generation scaffolds require dynamic drug and growth factor delivery.
- Synergistic interaction between structural support and delivery is key for optimal regeneration.
Purpose of the Study:
- To review common tissue engineering materials.
- To explore strategies for incorporating drug delivery systems into scaffolds.
- To highlight the synergistic interaction between scaffold properties and drug delivery.
Main Methods:
- Review of electrospun polymers and hydrogels as common scaffold materials.
- Analysis of strategies for integrating drug delivery functionalities.
- Discussion of the interplay between material properties and therapeutic agent release.
Main Results:
- Electrospun polymers and hydrogels are versatile scaffold materials.
- Various strategies exist for incorporating controlled drug release.
- Synergy between scaffold mechanics and drug delivery enhances regenerative potential.
Conclusions:
- Optimizing tissue engineering scaffolds requires integrating structural support with controlled drug delivery.
- Electrospun polymers and hydrogels offer promising platforms for such integrated systems.
- Further research into synergistic design is crucial for advancing regenerative medicine.
