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Updated: Feb 17, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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CDK4 expression in chordoma: A potential therapeutic target

Tang Liu1,2, Jacson K Shen1, Edwin Choy1

  • 1UCLA Orthopaedic Surgery, Sarcoma Biology Laboratory, 615 Charles E Young Dr. South, Biomedical Sciences Research Building, Room 410, Los Angeles, CA 90095.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|December 2, 2017
PubMed
Summary

Targeting cyclin-dependent kinase 4 (CDK4) shows promise for chordoma treatment. High CDK4 expression in chordoma tissues correlates with metastasis and recurrence, and inhibiting it slows tumor growth.

Keywords:
CDK4CDK6chordomap16INK4Apalbociclib

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