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Birth defect survival for Hispanic subgroups.

Keila N Lopez1, Wendy N Nembhard2, Ying Wang3

  • 1Division of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

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|December 2, 2017
PubMed
Summary
This summary is machine-generated.

Mortality rates for Hispanic children with birth defects vary significantly by subgroup. Cuban American children had the highest survival, while Mexican American children faced the highest mortality risk, especially with cardiovascular defects.

Keywords:
Hispanicbirth defectscongenital heart diseasehealth disparitiespublic healthsurvival

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Area of Science:

  • Pediatric Health
  • Public Health
  • Genetics and Genomics

Background:

  • Infant and childhood mortality rates for birth defects show disparities across maternal race/ethnicity.
  • Limited data exists on mortality for Hispanic ethnic subgroups with birth defects.

Purpose of the Study:

  • To analyze survival and mortality differences among Hispanic infants and children with major birth defects.
  • To identify specific Hispanic ethnic subgroups with varying mortality risks.
  • To understand the impact of clinical and demographic factors on mortality.

Main Methods:

  • Retrospective cohort study of 28,497 Hispanic children with major birth defects (1999-2007).
  • Utilized data from 12 population-based state birth defects surveillance programs.
  • Employed Kaplan-Meier survival analysis and Cox proportional hazards regression.

Main Results:

  • One-year survival was highest for Cuban infants (94.6%) and lowest for Mexican infants (90.2%).
  • Survival up to age 8 remained highest for Cuban Americans and lowest for Mexican Americans.
  • Mexican infants with cardiovascular defects showed a higher mortality risk compared to non-Hispanic Whites.

Conclusions:

  • Significant survival differences exist among Hispanic ethnic subgroups with birth defects.
  • Cuban American children exhibited the highest survival rates, whereas Mexican American children had the lowest.
  • Findings highlight the need for subgroup-specific analyses within the Hispanic population to address health disparities.