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Updated: Feb 17, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

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Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study

Tatsuya Maruhashi1, Junko Soga1, Noritaka Fujimura1

  • 1Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Atherosclerosis
|December 2, 2017
PubMed

Insights

Baseline brachial artery diameter is less accurate than flow-mediated vasodilation for assessing cardiovascular risk in men. FMD is a superior predictor of cardiovascular events and disease compared to BBA diameter.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diagnostic Accuracy

Background:

  • Baseline brachial artery (BBA) diameter is a potential confounder for flow-mediated vasodilation (FMD) measurements.
  • Cardiovascular risk factors and disease prevalence increase with BBA diameter and FMD.

Purpose of the Study:

  • Evaluate relationships between BBA diameter and cardiovascular risk factors.
  • Compare diagnostic accuracy of BBA diameter versus FMD in identifying cardiovascular risk.

Main Methods:

  • Measured BBA diameter and FMD in 5695 male subjects.
  • Retrospectively analyzed cardiovascular events in 440 male subjects.
  • Utilized receiver operating characteristic (ROC) curves to assess diagnostic accuracy.

Main Results:

  • BBA diameter and FMD correlated with age, BMI, blood pressure, lipids, glucose, and Framingham risk score.
  • Diagnostic accuracy (AUC) for BBA diameter was significantly lower than FMD for identifying subjects without risk factors, patients with CVD, and predicting cardiovascular events.
  • FMD demonstrated superior predictive value for cardiovascular events.

Conclusions:

  • Baseline brachial artery diameter is inferior to flow-mediated vasodilation for cardiovascular risk assessment in men.
  • FMD is a more reliable biomarker for cardiovascular risk stratification.
Abstract

Keywords:
AtherosclerosisBaseline brachial artery diameterCardiovascular risk factorFlow-mediated vasodilation

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