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TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells

Dan-Dan Xu1, Xiao-Feng Li2, Yu-Huan Li2

  • 1Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; Pharmacy Department, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.

Biochemical and Biophysical Research Communications
|December 3, 2017
PubMed

Insights

Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) protects against liver fibrosis. Overexpressing TIPE2 inhibits hepatic stellate cell activation and proliferation, suggesting its therapeutic potential.

Area of Science:

  • Hepatology
  • Immunology
  • Cell Biology

Background:

  • TIPE2 (TNFAIP8L2) regulates inflammation and immune homeostasis.
  • TIPE2 is implicated in tumor and proliferative disease development.
  • Hepatic stellate cells (HSCs) are key players in liver fibrosis.

Purpose of the Study:

  • To investigate the role of TIPE2 in HSC-T6 cell activation and proliferation.
  • To determine TIPE2's impact on liver fibrosis development.

Main Methods:

  • Assessed TIPE2 expression in primary HSCs and HSC-T6 cells.
  • Utilized GV141-TIPE-2 for TIPE2 overexpression.
  • Employed TIPE-2 siRNA for TIPE2 inhibition.
  • Monitored HSC activation, proliferation, and expression of β-Catenin, Cmyc, and Cyclin D1.

Main Results:

  • Low TIPE2 expression observed in CCl4-treated mice HSCs and activated HSC-T6 cells.
  • TIPE2 overexpression suppressed HSC-T6 cell activation, proliferation, and key protein expressions.
  • TIPE2 inhibition promoted HSC activation and proliferation.

Conclusions:

  • TIPE2 exhibits a protective role in liver fibrosis.
  • TIPE2 acts as an inhibitor of HSC activation and proliferation.
  • TIPE2 represents a potential therapeutic target for liver fibrosis.
Keywords:
Hepatic stellate cells (HSCs)Liver fibrosisTNFAIP8L2

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