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Related Experiment Video

Updated: Feb 17, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Alternative activation generates IL-10 producing type 2 innate lymphoid cells.

Corey R Seehus¹, Asha Kadavallore¹, Brian de la Torre¹

¹Research Division of Immunology, Departments of Biomedical Sciences and Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.

Nature Communications

|December 3, 2017

Summary

Researchers discovered a new subset of Type 2 innate lymphoid cells (ILC2), called ILC2₁₀, which produce IL-10. These cells have unique activation pathways and may play a role in immune regulation.

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Area of Science:

Immunology
Cell Biology

Background:

Type 2 innate lymphoid cells (ILC2) share features with CD4+ T helper 2 (Th2) cells.
The functional diversity within the ILC2 lineage remains incompletely understood.

Purpose of the Study:

To investigate the functional diversity of ILC2.
To identify and characterize novel ILC2 subsets.

Main Methods:

Induction of ILC2 subsets in lung tissue.
Analysis of gene expression and cytokine production.
In vivo studies involving IL-2 administration and assessment of immune cell populations.

Main Results:

A distinct subset of activated lung ILC2, termed ILC2₁₀, was identified.
ILC2₁₀ cells produce IL-10 and downregulate pro-inflammatory genes.
IL-2 promotes ILC2₁₀ generation and is associated with reduced eosinophil recruitment.
ILC2₁₀ exhibits characteristics of effector and memory cell generation, with a subset persisting after stimulation cessation.

Conclusions:

A previously unrecognized IL-10 producing ILC2 effector cell population (ILC2₁₀) has been discovered.
ILC2₁₀ cells represent a distinct activation pathway within the ILC2 lineage.
These findings expand our understanding of ILC2 functional heterogeneity and potential immunoregulatory roles.