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Alzheimer's Disease: Past, Present, and Future.
Mark W Bondi1, Emily C Edmonds1, David P Salmon2
11Department of Psychiatry,University of California San Diego,School of Medicine,La Jolla,California.
Journal of the International Neuropsychological Society : JINS
|December 5, 2017
Summary
Research on dementia, particularly Alzheimer's disease (AD), has rapidly advanced over the last century. Modern studies now focus on early detection using biomarkers and prodromal stages like mild cognitive impairment.
Area of Science:
- Neuroscience
- Neurology
- Gerontology
Background:
- Dementia's understanding has evolved significantly over the past century, accelerating since the 1980s.
- Early research focused on characterizing neuropsychological deficits and differentiating dementia types.
- Historical texts suggest awareness of cognitive decline predates modern scientific understanding.
Observation:
- The 1990s identified cognitive mechanisms linked to neuropathology.
- The 2000s emphasized studying mild cognitive impairment (MCI) as a prodromal stage.
- Current research utilizes imaging and biomarkers for preclinical disease detection.
Findings:
- Neuropsychological profiling and dementia differentiation were foundational in the 1980s.
- Specific cognitive mechanisms affected by neuropathology were identified in the 1990s.
- Biomarkers are now crucial for characterizing preclinical neurodegenerative disease.
Implications:
- Future research directions include therapeutic interventions and advanced diagnostic tools.
- Understanding prodromal stages like MCI is key to early intervention.
- Continued research promises improved characterization and treatment of dementia.
Keywords:
Alzheimer’s diseaseBiomarkersClinical trialsCognitionMild cognitive impairmentNeuroimagingNeuropsychologyNeuroscienceMore Related Videos
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