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Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

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Published on: May 20, 2020

Equine renal hemangiosarcoma: clinical presentation, pathologic features, and pSTAT3 expression.

Katherine Hughes, Victoria H L Scott, Maximilian Blanck¹

¹2 Horizon Discovery, Waterbeach, Cambridge, UK.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

|December 5, 2017

Summary

This summary is machine-generated.

This study details three equine renal hemangiosarcoma cases, including a rare epithelioid variant. Phosphorylated STAT3 (pSTAT3) expression was evaluated, offering insights into tumor development.

Keywords:

Epithelioid STAT3 hemangiosarcoma horse kidney renal skin

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Area of Science:

Veterinary Pathology
Oncology
Molecular Biology

Background:

Hemangiosarcoma is a rare tumor in horses.
Equine renal hemangiosarcoma presents diagnostic challenges.
Understanding tumor pathogenesis is crucial for equine cancer research.

Observation:

Characterization of three equine renal hemangiosarcoma cases.
Identification of the epithelioid variant in one case.
Assessment of phosphorylated STAT3 (pSTAT3) nuclear expression in neoplastic cells.

Findings:

Clinical signs included weight loss, nasal discharge, epistaxis, and abdominal pain.
Two hemangiosarcomas showed classical histopathology; one exhibited an epithelioid morphology.
pSTAT3 expression was prominent in the epithelioid variant but variable in others, with stromal activity noted in metastases.

Implications:

The findings contribute to the understanding of equine renal hemangiosarcoma, particularly the epithelioid variant.
pSTAT3 activation may play a role in the pathogenesis of some equine hemangiosarcomas.
Further research into STAT3 signaling could reveal therapeutic targets for equine cancers.