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Published on: August 13, 2019
Selective progesterone receptor modulators: new possibilities for gynecologic hormone therapy
Progesterone and its synthetic analogs are vital in gynecology, acting through progesterone receptors. Selective progesterone receptor modulators like mifepristone and ulipristal acetate offer new therapeutic options for various reproductive health conditions.
Area of Science:
- Reproductive endocrinology
- Pharmacology
- Gynecology
Background:
- Progesterone is a key hormone regulating female reproductive functions.
- Synthetic progestins and progesterone are widely used in gynecological practice.
- Progesterone receptors mediate the effects of these steroids and selective progesterone receptor modulators (SPRMs).
Purpose of the Study:
- To review the role of progesterone and its receptor modulators in reproductive health.
- To highlight the clinical applications of SPRMs in gynecology.
Main Methods:
- Literature review of progesterone's role in reproductive functions.
- Analysis of clinical applications of progesterone and SPRMs.
- Summary of current therapeutic uses of mifepristone and ulipristal acetate.
Main Results:
- Progesterone and synthetic progestins exert effects via progesterone receptors.
- Selective progesterone receptor modulators represent a newer class of drugs targeting these receptors.
- Mifepristone and ulipristal acetate are two SPRMs currently in clinical use with distinct indications.
Conclusions:
- Progesterone receptor modulators offer versatile therapeutic applications in gynecology.
- Mifepristone is indicated for abortion and labor induction.
- Ulipristal acetate is used for emergency contraception and uterine fibroid management.
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