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Related Concept Videos

Protein Organization01:24

Protein Organization

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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Related Experiment Video

Updated: Feb 17, 2026

Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae
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Using more than 801 296 small-molecule crystal structures to aid in protein structure refinement and analysis.

Jason C Cole1, Ilenia Giangreco1, Colin R Groom1

  • 1Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, England.

Acta Crystallographica. Section D, Structural Biology
|December 5, 2017
PubMed
Summary
This summary is machine-generated.

This addendum acknowledges key contributions to protein structure solution methods. It highlights the use of Cambridge Structural Database data for advancing crystallographic techniques.

Keywords:
Cambridge Structural Databaseaddendummacromolecular crystallographyscripting

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Area of Science:

  • Crystallography
  • Structural Biology
  • Biochemistry

Background:

  • The development of protein structure solution methods is crucial for understanding biological processes.
  • The Cambridge Structural Database (CSD) contains a vast amount of chemical structure information.
  • Previous work by Cole et al. (2017) introduced advancements in protein structure determination.

Purpose of the Study:

  • To provide an addendum to the Introduction of Cole et al. (2017).
  • To recognize the foundational work of Bricogne, Smart, and others.
  • To highlight the significance of Cambridge Structural Database data in protein structure solution.

Main Methods:

  • Review of historical contributions to crystallographic methods.
  • Analysis of the impact of the Cambridge Structural Database on structural biology.
  • Integration of prior research findings into the context of Cole et al. (2017).

Main Results:

  • Acknowledgement of Bricogne, Smart, and colleagues' pioneering efforts.
  • Recognition of the essential role of Cambridge Structural Database data.
  • Contextualization of these contributions within the framework of protein structure solution.

Conclusions:

  • The development of protein structure solution is a cumulative effort.
  • The Cambridge Structural Database has been instrumental in advancing structural biology.
  • Proper attribution is essential for scientific progress and historical accuracy.