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Updated: Feb 17, 2026

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
Published on: March 12, 2021
Combining information from multiple complex surveys
Qi Dong1, Michael R Elliott2, Trivellore E Raghunathan3
1Google, Inc., 1R4A, Quad 5, Google Inc, 399 N. Whisman Road, Mountain View, CA 94043. qdong@google.com.
Abstract:
This manuscript describes the use of multiple imputation to combine information from multiple surveys of the same underlying population. We use a newly developed method to generate synthetic populations nonparametrically using a finite population Bayesian bootstrap that automatically accounting for complex sample designs. We then analyze each synthetic population with standard complete-data software for simple random samples and obtain valid inference by combining the point and variance estimates using extensions of existing combining rules for synthetic data. We illustrate the approach by combining data from the 2006 National Health Interview Survey (NHIS) and the 2006 Medical Expenditure Panel Survey (MEPS).
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