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[Tracheobronchial wheezing of childhood turning into asthma?]

E M Rocha1

  • 1Congrès National des pédiatres portugais, Lisbonne.

Allergie Et Immunologie
|January 1, 1989
PubMed

Insights

Wheezy bronchitis and asthma in children share allergic and bronchial hyperreactivity mechanisms, with asthma showing more severe symptoms. Early identification and treatment of atopic wheezy bronchitis are crucial as it can progress to asthma.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Pediatrics

Context:

  • Distinguishing between wheezy bronchitis and perennial asthma in children is essential for appropriate management.
  • Asthma and wheezy bronchitis present with overlapping symptoms, necessitating detailed investigation into underlying mechanisms.

Purpose:

  • To investigate the differences in allergic, immunological, functional, and bronchial hyperreactivity (BHR) between children with wheezy bronchitis and perennial asthma.
  • To compare the prevalence of positive skin prick tests (SPT), elevated IgE levels, and BHR to acetylcholine in these pediatric groups.

Summary:

  • A study of 285 children (ages 4-13) compared asthma, wheezy bronchitis, and control groups using SPT, IgE tests, respiratory function tests, and acetylcholine challenges.
  • Asthmatic children exhibited significantly higher rates of positive SPT, RAST, functional abnormalities, and acetylcholine sensitivity compared to those with wheezy bronchitis.
  • Wheezy bronchitis cases showed evidence of allergic-immunological mechanisms and BHR, albeit to a lesser degree than asthma, indicating a close link between the conditions.

Impact:

  • Findings suggest that wheezy bronchitis involves similar, but milder, allergo-immunological and BHR mechanisms as asthma.
  • Highlights the importance of monitoring children with wheezy bronchitis, as a significant number may develop overt asthma.
  • Recommends treating atopic wheezy bronchitis as atopic asthma due to the shared underlying pathology and potential for progression.

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