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Endocrine Signaling01:45

Endocrine Signaling

68.3K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

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Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
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What is the Endocrine System?00:46

What is the Endocrine System?

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The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
422.2K
Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

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Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
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Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

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Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
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Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

7.0K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
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Updated: Feb 17, 2026

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

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Pre-operative Endocrine Therapy.

Laura M Arthur1, Arran K Turnbull1, Lucy R Khan2

  • 1Edinburgh Breast Cancer Now Research Team, Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, Western General Hospital, The University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU Scotland.

Current Breast Cancer Reports
|December 5, 2017
PubMed
Summary
This summary is machine-generated.

Pre-operative endocrine therapy is a valuable treatment for ER-positive breast cancer in postmenopausal women. Emerging research explores new combinations and targeted drugs for improved outcomes.

Keywords:
Aromatase inhibitorBreast cancerEndocrine therapyNeoadjuvantPre-operativeTamoxifen

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Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Pre-operative endocrine therapy has evolved significantly over four decades.
  • It is now a valid treatment for postmenopausal women with ER-rich breast cancer.

Purpose of the Study:

  • To review established evidence and emerging data on pre-operative endocrine therapy.
  • To discuss new approaches in the treatment of ER-positive breast cancer.

Main Methods:

  • Review of current literature on neoadjuvant endocrine therapy.
  • Analysis of emerging data from metastatic and neoadjuvant settings.

Main Results:

  • Pre-operative endocrine therapy is effective in down-staging large or locally advanced ER+ breast cancers.
  • Emerging data supports dual endocrine targeting and combinations with PI3K pathway and cell cycle inhibitors.
  • Routine peri-operative endocrine therapy may provide prognostic information and guide adjuvant treatment.

Conclusions:

  • Pre-operative endocrine therapy is an evolving field with novel therapeutic strategies.
  • Established evidence and new data highlight its applications in ER-positive breast cancer management.