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Updated: Jan 7, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
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Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

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Locoregional Considerations for Invasive Lobular Carcinoma.

Rita A Mukhtar1,2, Meghan R Flanagan3

  • 1Division of Surgical Oncology, University of California, San Francisco, CA USA.

Current Breast Cancer Reports
|December 30, 2025
PubMed
Summary
This summary is machine-generated.

Locoregional management of invasive lobular carcinoma (ILC) is feasible with breast conservation therapy, oncoplastic surgery, and neoadjuvant chemotherapy. Further ILC-specific studies are essential to address knowledge gaps in managing this common breast cancer subtype.

Keywords:
Breast surgeryInvasive lobularLobular breast cancerLobular carcinomaLocoregional management

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Invasive lobular carcinoma (ILC) is the second most common type of invasive breast cancer, presenting unique challenges in locoregional management.
  • Current literature review focuses on optimizing surgical and systemic treatment approaches for ILC patients.

Purpose of the Study:

  • To summarize recent advancements in the locoregional management of invasive lobular carcinoma.
  • To review current evidence on breast surgery, axillary staging, and neoadjuvant therapy for ILC.

Main Methods:

  • Systematic literature review of recent studies on ILC management.
  • Analysis of data regarding breast conservation, margin status, axillary surgery, and neoadjuvant treatment efficacy.

Main Results:

  • Breast conservation therapy is safe for ILC, though high positive margin rates can be mitigated by shave margins and oncoplastic techniques.
  • Evidence for de-escalating axillary surgery in ILC is insufficient; sentinel lymph node biopsy is generally recommended.
  • Neoadjuvant chemotherapy shows potential for improving breast conservation and increasing nodal complete response in select ILC patients.

Conclusions:

  • Locoregional management of ILC requires tailored approaches due to its distinct biological and clinical characteristics.
  • Further ILC-specific research is crucial to refine treatment guidelines and address existing knowledge gaps.