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Efficacy of potassium polycitrate on renal stone and microlithiasis predisposed by metabolic disorders
Hadi Sorkhi1, Nazanin Saeedizand2, Mohammad Poornasrollah3
1Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol.
Insights
Potassium citrate effectively treats kidney stones and microlithiasis in children under two. Treatment efficacy is not affected by specific metabolic disorders, but children with these conditions show a better response.
Area of Science:
- Pediatric Nephrology
- Urology
- Metabolic Disorders
Background:
- High prevalence of renal stones in pediatric populations.
- Focus on children under two years with renal stones or microlithiasis.
- Investigating the link between treatment efficacy and metabolic abnormalities.
Purpose of the Study:
- To evaluate potassium citrate efficacy for pediatric renal stones.
- To assess the correlation between treatment response and metabolic disorders.
- To determine optimal treatment strategies for young children.
Main Methods:
- Cross-sectional study of 100 pediatric patients (<2 years).
- Evaluation for metabolic disorders and treatment with potassium citrate.
- Follow-up via ultrasonography and assessment of treatment response.
Main Results:
- Hyperuricosuria and hypercalciuria were the most common metabolic disorders (40%, 33%).
- Potassium citrate showed high efficacy, with 73% complete response.
- No significant difference in efficacy based on metabolic disorder type, but children with disorders responded better.
Conclusions:
- Potassium citrate is recommended for all children under two with renal stones or microlithiasis.
- Treatment is particularly beneficial for pediatric patients with co-existing metabolic disorders.
- Further research into metabolic links in pediatric nephrolithiasis is warranted.
Background:
According to high prevalence of renal stone in children, we evaluated the efficacy of treatment with potassium citrate and its correlation with metabolic disorders in children less than two years of age with renal stone and microlithiasis.
Methods:
In this cross- sectionaly study, 100 patients (less than 2 years old) with renal stone or microlitiasis were evaluated for metabolic disorders. They were treated with potassium citrate and followed-up by ultrasonography every 3 months. Then response to treatment was evaluated according to the fresence metabolic disorders (A p-alue<0.05 was significant).
Results:
According to this study, hyperuricosuria and hypercalciuria were the two major metabolic disorders (40-33%). Seventy three patients had complete response, and also there as not a significant difference (p<0.05) in the efficacy of treatment due to types of metabolic disorders. There was significant difference between relative response to treatment in children who had metabolic disorders and patient without any metabolic disorders.
Conclusion:
Based on our results the use of potassium citrate in all children less than 2 years with renal stone or microlithiasis especially those with metabolic disorders, are recommended.
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