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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

533
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
533
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

477
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
477

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Related Experiment Video

Updated: Feb 17, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Liver Transplantation Update: 2014.

Serkan Dogan1, Ahmet Gurakar2

  • 1Department of Gastroenterology, Johns Hopkins School of Medicine, Maryland, United States.

Euroasian Journal of Hepato-Gastroenterology
|December 5, 2017
PubMed
Summary

Liver transplantation (LT) offers a life-saving treatment for end-stage liver disease and acute liver failure. Advances in surgical techniques and immunosuppression have significantly improved survival rates, though organ shortage remains a challenge.

Keywords:
Acute liver failureCardiac calcium scoreCirrhosisCoronary artery diseaseHepatitis CHepatocellular carcinomaLiver transplantationMilan criteriaModel for end-stage liver diseaseUCSF criteria.

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Area of Science:

  • Hepatology and Transplant Surgery
  • Medical Innovation and Patient Outcomes

Background:

  • Liver transplantation (LT) is the gold standard for end-stage liver disease (ESLD), acute liver failure (ALF), and certain liver tumors.
  • Survival rates have improved significantly due to surgical, intensive care, and immunosuppression advancements.
  • The Model for End-Stage Liver Disease (MELD) score is crucial for prioritizing patients, with exceptions for hepatocellular carcinoma (HCC).

Purpose of the Study:

  • To summarize recent advances in liver transplantation knowledge.
  • To discuss factors influencing pre-transplant outcomes and post-transplant survival.
  • To highlight challenges like organ shortage and common causes of mortality.

Main Methods:

  • Review of recent advancements in liver transplantation.
  • Analysis of factors influencing transplant outcomes, including MELD score and HCC criteria.
  • Discussion of strategies to expand the donor pool and common post-transplant complications.

Main Results:

  • Liver transplantation survival rates are 85-90% at 1 year and ~50% at 10 years.
  • Innovations like split grafts, marginal donors, and live donor liver transplantation (LDLT) address organ shortages.
  • Common causes of death include hepatitis C virus (HCV) recurrence and coronary artery disease (CAD).

Conclusions:

  • Liver transplantation remains a critical therapy for liver failure and tumors, with ongoing improvements in outcomes.
  • Addressing organ donor shortages through innovative techniques is essential.
  • Managing post-transplant complications like HCV recurrence and CAD is vital for long-term patient survival.