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Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
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Hepatic Venous Pressure Gradient Measurement in Bangladeshi Cirrhotic Patients: A Correlation with Child's Status,

Mamun Al Mahtab1, Sheikh M Noor E Alam1, Mohammad A Rahim2

  • 1Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh.

Euroasian Journal of Hepato-Gastroenterology
|December 5, 2017
PubMed

Insights

Hepatic venous pressure gradient (HVPG) measurement is crucial for assessing liver cirrhosis severity. Higher HVPG levels correlate with advanced Child-Pugh status and increased risk of variceal bleeding in cirrhotic patients.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Hepatic venous pressure gradient (HVPG) is a key indicator of portal pressure in cirrhotic portal hypertension.
  • Assessing the relationship between HVPG, variceal size, Child-Pugh status, and bleeding is vital for patient management.

Purpose of the Study:

  • To evaluate the correlation between HVPG and the severity of liver cirrhosis.
  • To determine the association of HVPG with variceal size, Child-Pugh classification, and history of variceal bleeding.

Main Methods:

  • Prospective study involving 96 patients diagnosed with liver cirrhosis.
  • HVPG measurement performed via the transfemoral route.
  • Clinical, biochemical, and upper gastrointestinal endoscopy evaluations conducted, with cirrhosis severity assessed by Child's status.

Main Results:

  • Mean HVPG was significantly higher in Child's B and C patients compared to Child's A (p=0.011 for A vs B, p=0.041 for A vs C).
  • Patients with a history of variceal bleeding exhibited higher mean HVPG than non-bleeding patients with large varices (17.7 ± 5.5 vs 14.9 ± 4.7 mmHg, p=0.006).

Conclusions:

  • HVPG measurement is a valuable tool for assessing the severity of liver cirrhosis.
  • HVPG levels are significantly associated with Child-Pugh status and the risk of variceal bleeding in cirrhotic patients.
Abstract

Keywords:
Hepatic venous pressure gradientPortal pressureVariceal bleeding.Child-Turcotte-Pugh

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